A REVIEW OF COUMARIN DERIVATIVES IN PHARMACOTHERAPY

BALLAZHI, Lulzime and Alili Idrizi, Edita and DAUTI, Merita and Rustemi Ahmeti, Hanife and Yzeiri Havziu, Drita (2023) A REVIEW OF COUMARIN DERIVATIVES IN PHARMACOTHERAPY. ACTA MEDICA BALKANICA International Journal of Medical Sciences, 8 (15-16). pp. 234-243. ISSN 2545 - 4870

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Abstract

Coumarins are proven precursors in the synthesis of many medicinal compounds and the heterocycles derived from them are widely appreciated for their numerous pharmacological effects. Molecules containing coumarin rings have been studied for their antiviral, antimicrobial, antifungal, anti-inflammatory, anticonvulsant, anticoagulant, antipsychotic, and anticancer effects. Thus, the isolation, structural characterization, and pharmacological evaluation of new derivatives combining coumarin rings continuously provoke research interest. In this paper, a brief overview of the chemical, biopharmaceutical, pharmacokinetic, and pharmacological properties, as well as the structure-activity relationship for many coumarin derivatives, is given, with a special focus on new compounds as potential chemotherapeutics or key components for the synthesis of drugs intended for the treatment of cancer.

Item Type:	Article
Uncontrolled Keywords:	coumarins, pharmacological effect, SAR, cancer.
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User:	Unnamed user with email zshi@unite.edu.mk
Date Deposited:	24 Sep 2023 13:49
Last Modified:	24 Sep 2023 13:49
URI:	http://eprints.unite.edu.mk/id/eprint/1215

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