SYNTHESIS OF N-BENZAMIDOMETHYL - 4 -TOLUENESULFONAMIDE BY TWO DIFFERENT SYNTHETIC METHODS

ALILI, Agron and Abdija, Zulxhevat and Abduli, Shemsedin (2023) SYNTHESIS OF N-BENZAMIDOMETHYL - 4 -TOLUENESULFONAMIDE BY TWO DIFFERENT SYNTHETIC METHODS. Journal of Natural Sciences and Mathematics of UT, 8 (15-16). pp. 47-60. ISSN 2545-4072

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Abstract

Sulfonamide drugs paved the way for the antibiotic revolution in medicine. The sulfonamide chemical part is also present in other medications that are not antimicrobials, including thiazide diuretics, loop diuretics, anti-diabetic drugs, COX-2 inhibitors, etc. To make new derivatives of sulfa-drugs, test reactions by different synthetic procedures were performed to obtain N- benzamidomethyl-4-toluenesulfonamide. By two different synthetic procedures, N-benzamidomethyl-4-toluenesulfonamide was obtained in high yields. Reaction) with 4-toluene sulfonamides and (benzamidomethyl)triethylammonium chloride were performed at room temperature in ethanol/water solutions (pH ≥ 9). The other synthetic method was performed in dichloromethane or water depending on the solubility of N-benzamidomethylamine. The structure of N-Benzamidomethyl -4-toluenesulfonamide was confirmed and characterized by IR, 1H–NMR, 13C–NMR, UV, and MS spectrometry.

Item Type:	Article
Uncontrolled Keywords:	sulfonamide, benzamidomethyl, derivative
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User:	Unnamed user with email zshi@unite.edu.mk
Date Deposited:	04 Nov 2023 20:44
Last Modified:	04 Nov 2023 20:44
URI:	http://eprints.unite.edu.mk/id/eprint/1500

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