PERIAPICAL INFLAMMATORY LESIONS AND DIABETES MELLITUS TYPE II– A REVIEW

Salihu Fazliu, Aferdita and Kacarska, Marina and Halimi, Uran and Kolgeci, Blerina and Fazliu, Gazmend (2024) PERIAPICAL INFLAMMATORY LESIONS AND DIABETES MELLITUS TYPE II– A REVIEW. ACTA MEDICA BALKANICA International Journal of Medical Sciences, 9 (17-18). pp. 21-27. ISSN 2545 - 4870

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Abstract

Periapical periodontitis is a chronic inflammatory disease, caused by endodontic infection, and its development is regulated by the host immune/inflammatory response. Metabolic disorders, which are largely dependent on life style such as eating habits, have been interpreted as a “metabolically-triggered” low-grade systemic inflammation and may interact with periapical periodontitis by triggering immune modulation. Diabetes mellitus (DM) is a group of complex multisystem metabolic disorders due to a deficiency in insulin secretion caused by pancreatic β-cell dysfunction and/or insulin resistance in liver and muscle. Objective: In this paper, the current status of knowledge regarding the relationship between periapical inflammation and diabetes mellitus type II is reviewed. Material and method: Research was conducted on scientific papers published on Medline - Pub med in the past 10 years (from 2012-2022). The search was performed using the Mesh (Medical Subject Headings) key words: periapical inflammatory lesions, periapical periodontitis and diabetes mellitus type II. Results: Several studies have analyzed the possible association between periapical inflammatory lesions and diabetes mellitus type II. The results of studies carried mainly in animal models, less in humans suggested association between endodontic variables such as apical periodontitis, root canal treatment and diabetes mellitus type 2.The demonstration of association does not prove by itself the existence of a cause-effect relationship. Conclusion: A review of the literature showed connection between periapical inflammatory lesions and diabetes mellitus type II, but prospective case control clinical studies are needed for further clarifying this relation.

Item Type:	Article
Uncontrolled Keywords:	periapical inflammatory lesions, periapical periodontitis, diabetes mellitus type II.
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User:	Unnamed user with email zshi@unite.edu.mk
Date Deposited:	01 Oct 2024 08:07
Last Modified:	01 Oct 2024 08:07
URI:	http://eprints.unite.edu.mk/id/eprint/1732

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