PREVALENCE OF MIGRAINE IN PATENT FORAMEN OVALE ASSOCIATED STROKE

DJAMBAZOVSKA ZIKOVA, Sanja and VOJTIKIV SAMOILOVSKA, Danijela and JOVEVSKA, Svetlana and ARSOVSKA, Anita and PETRESKA, Jasna and DONEVA, Ana and CEPREGANOVA CANGOVSKA, Tatjana (2025) PREVALENCE OF MIGRAINE IN PATENT FORAMEN OVALE ASSOCIATED STROKE. International Journal of Medical Sciences, 10 (19-20). pp. 280-287. ISSN 2545 - 4870

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Abstract

Migraine is one of the most common neurological disorders which, despite being benign in nature, can be associated with stroke. The coexistence of migraine with a patent foramen ovale (PFO) - a known risk factor for stroke in young patients, further supports this connection. This paper investigates the prevalence of migraine in patients with cryptogenic stroke or transient ischemic attack associated with PFO. The study hypothesizes that migraine, particularly in younger patients, may be linked to strokes related to PFO through right-to-left shunt (RLS) detected by contrast-enhanced transcranial Doppler ultrasonography (Bubble-cTCD). We conducted a prospective observational study on 86 patients aged 18-60 years, assessing the presence of RLS and migraine history. RLS was detected in 56.6% of patients with cryptogenic stroke or transient ischemic attack and in 18.18% of patients with stroke or transient ischemic attack of known cause. A significant association was found between a history of migraine and cryptogenic stroke or transient ischemic attack with RLS (p < 0.04). A history of migraine was reported in 33.33% of patients with RLS and in 8.7% of those without RLS. In conclusion, our results showed a statistically significant association between migraine and cryptogenic stroke patients with RLS, supporting the notion that PFO-related stroke is an important subgroup among younger stroke patients with migraine. This work contributes to the growing body of evidence, strengthening the connection between migraine, PFO, and stroke, and deepening the understanding of the underlying mechanisms that link these conditions

Item Type:	Article
Uncontrolled Keywords:	migraine, right-to-left shunt, cryptogenic stroke, patent foramen ovale, Bubble- transcranial Doppler ultrasonography
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User:	Unnamed user with email zshi@unite.edu.mk
Date Deposited:	26 Dec 2025 00:56
Last Modified:	26 Dec 2025 00:56
URI:	http://eprints.unite.edu.mk/id/eprint/2291

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