Rama, Ariol (2021) ASSOCIATION OF RS1333049 POLYMORPHISM ON 9p21 LOCUS WITH CORONARY ARTERY DISEASE IN ALBANIAN PATIENTS. International Journal of Medical Sciences, 6 (11-12). pp. 11-17. ISSN 2545 - 4870

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An association between rs1333049 polymorphism on Chr9p21 and coronary artery disease (CAD) has been reported in multiple studies. Rising trends in coronary heart disease in Albania requires in-depth analysis of socio-economic as well as genetic factors. The purpose of this study was to investigate the association between rs1333049 variant and the presence of CAD in Albanian patients. This was a case-control study involving 177 patients who underwent coronary angiography at the cardiology department at Hygeia Hospital in Tirana, Albania. Patients were divided into two groups; CAD and no-CAD, based on severity and the number of atherosclerotic lesions. Genotypes were determined by allele specific polymerase chain reaction. Allelic and genotype frequencies were determined and tested against Hardy-Weinberg equilibrium. Odds ratio (ORs) and 95% CI were analyzed by logistic regression for p <0.05. The risk associated with rs1333049 polymorphism and CAD was evaluated and adjusted for risk factors. We replicated rs1333049 C-allele association with CAD (OR=1.71 [95%CI: 1.10-2.66], p=0.0165). In addition, under recessive model of inheritance, and after adjustment for covariates, we observed an association of the homozygous genotype (CC) of rs1333049 with coronary artery disease (OR adjusted=2.22 [95%CI: 1.09 – 4.54], p=0.02278). Similarly, under log-additive model of inheritance, homozygous carriers of rs1333049 C-allele were associated with increased risk of CAD (OR adjusted= 1.81 [95% CI; 1.12 – 2.94], p= 0.01360). Our results provide substantial evidence for the association of rs1333049 polymorphism with CAD in Albanian patients. Furthermore, CAD risk conferred by C-allele of rs1333049 polymorphism in our study was higher than the reported association of the risk allele-C with CAD in Caucasians of European origin. These results have significant importance in the light of increased incidence of coronary artery disease in Albania.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Unnamed user with email
Date Deposited: 24 Sep 2021 08:18
Last Modified: 24 Sep 2021 08:18

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