TIME-DEPENDENT EFFECTS OF ACUTE ORAL ADMINISTRATION OF AMITRAZ ON SERUM ENZYME ACTIVITY IN WISTAR RATS

SHAQIRI, Njomza and HAJRULAI-MUSLIU, Zehra and GJORGOSKI, Icko and VLAHOV, Jane and STOJKOVSKI, Velimir (2026) TIME-DEPENDENT EFFECTS OF ACUTE ORAL ADMINISTRATION OF AMITRAZ ON SERUM ENZYME ACTIVITY IN WISTAR RATS. In: 2026 International Congress "From Research to Application", 20 May 2026, University of Tetova, Tetova, North Macedonia.

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Abstract

This study is based on the investigation of the time-dependent effects of a single oral administration of amitraz (50 mg/kg) on serum enzyme activity in Wistar rats. Amitraz is a widely used acaricide with known neurotoxic and metabolic effects; however, its short-term biochemical impact requires further investigation. In this study, enzymatic activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), amylase (AMY) and lactate dehydrogenase (LDH) were assessed with an automated biochemical analyzer, at the following time points: 2 h, 24 h, 48 h and 7 days after one-time oral administration of amitraz 50mg/kg b.w. Using one-way analysis of variance (one-way ANOVA) to assess differences between experimental groups compared to the control group, the results showed no statistically significant changes in the hepatic and metabolic enzymatic activities assessed at 2 h and 7 days (p > 0.05) and significant at 24 h and 48 h time points (from p < 0.01 to p < 0.001). The results showed a consistent pattern, with the maximum peak observed at 48 h, while after 7 days, although in some cases there is still a slight increase, it is not significant and indicates a normalization of their activity. The results showed, that despite a single oral administration of amitraz, it can still cause hepatotoxicity and pancreatic alterations which appear to be reversible. It can be concluded that oral administration of amitraz causes moderate, time-dependent and reversible biochemical changes, mainly affecting hepatic, pancreatic and metabolic functions. These findings contribute to a better understanding of the acute toxicological profile of amitraz and highlight the importance of assessing the time course in toxicological studies.

Item Type: Conference or Workshop Item (Paper)
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Unnamed user with email zshi@unite.edu.mk
Date Deposited: 01 Jul 2026 09:18
Last Modified: 01 Jul 2026 09:18
URI: http://eprints.unite.edu.mk/id/eprint/2357

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