RENAL TOXICITY COMPARISON BY NSAIDS DEPENDING ON THE MECHANISM OF ACTION IN PATIENTS WITH HEADACHES

YZEIRI HAVZIU, Drita and Gjorgjeska, Biljana and HAXHIU ZAIMI, Arlinda and ALILI IDRIZI, Edita and ALIJA, Gjylaj and DAUTI, Merita and AMETI LIKA, Sihana and BALAZHI, Lulzime (2022) RENAL TOXICITY COMPARISON BY NSAIDS DEPENDING ON THE MECHANISM OF ACTION IN PATIENTS WITH HEADACHES. ACTA MEDICA BALKANICA -International Journal of Medical Sciences, 7 (13-14). pp. 46-54. ISSN 2545-4870

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Abstract

Non-selective COX inhibitors are the most widely prescribed NSAID treatment for headaches. Celecoxib is another NSAID therapy that has been approved in the last several years, with different mechanisms of action. Nonsteroidal anti-inflammatory drugs (NSAIDs) cause renal toxicity following the inhibition of cyclooxygenases. Relatively little is known about the comparative nephrotoxicity of NSAIDs in patients with a chronic headache based on COX inhibition. Therefore, this study was designed to compare the nephrotoxic effects of nonselective COX inhibitors, relatively selective inhibitors, and selective inhibitors based on the mechanism of action. Besides conventional markers of renal function (serum/urine creatinine determined by Jaffe's methods of enzymatic assay for urea in serum, uric acid in serum, and glutamyl transferase [ᵧ-GT] in serum). We used nephelometry by β2 microglobulin (β2M) and photoelectric colorimetry for microalbuminuria in urine, as well as ion selective electrode (ISE) for electrolyte detection in serum, to evaluate glomerular and tubular functioning. Kidney disease history was a requirement to be excluded from the study. The results showed increased values of microalbuminuria in patients treated with NSAIDs as non-selective COX inhibitors compared with patients treated with NSAIDs as relatively selective and highly selective COX-2 inhibitors - 52.8% (19), 16.7% (2), 16.7% (4), consequently and in β2 microglobulin 97.2% (35), 91.7% (11), 54.2% (13), consequently. The renoprotective properties of highly selective COX-2 inhibitors have been confirmed with non-selective COX inhibitors that are less nephrotoxic agents.

Item Type:	Article
Uncontrolled Keywords:	Nephrotoxicity, Nonsteroidal anti-inflammatory drugs, COX inhibitors, Headaches
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User:	Unnamed user with email zshi@unite.edu.mk
Date Deposited:	22 Sep 2022 14:02
Last Modified:	22 Sep 2022 14:02
URI:	http://eprints.unite.edu.mk/id/eprint/954

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