EFFICACY AND RATIONALE BEHIND COMBINATION OF THE ANTIOXIDANT THERAPY IN MEN WITH OLIGOASTENOZOOSPERMIA AND ELEVATED CASPASE-3 ACTIVITY

Zhaku, Vegim and BEADINI, Sheqibe and ÇEKA, Xheladin and BEADINI, Nexhbedin and DURMISHI, Naser (2022) EFFICACY AND RATIONALE BEHIND COMBINATION OF THE ANTIOXIDANT THERAPY IN MEN WITH OLIGOASTENOZOOSPERMIA AND ELEVATED CASPASE-3 ACTIVITY. International Journal of Medical Sciences, 7 (13-14). pp. 184-193. ISSN 2545-4870

Text Acta Medica Balkanica FINAL FINAL-184-193.pdf - Published Version Download (1MB)

Abstract

The rate of male infertility globally without exception has attracted the attention of healthcare professionals and pharmaceutical companies. To verify the effectiveness of combination therapy with antioxidants as recommended in some elaborated papers in major medical libraries such as PubMed, Cochrane, Scopus, and Elsevier, a total of 57 individuals were enrolled in the study after fulfilling the inclusion criteria. Standard semen analysis along with biochemical analysis of Caspase-3 levels was done before receiving therapy and after six months. The groups were randomly divided into the individuals who received the combination of the antioxidant formula (n=34) and the individuals who received placebo therapy (n=23). After 6 months of treatment, there was an improvement in concentration (mean & SD, 31.26 ± 3.39) and motility (46.18 ± 5.97) in the group that had received antioxidant therapy for 6 months with statistically significant difference (p<0.001), whereas the placebo group showed no statistically significant improvement after the 6 months in concentration (9.96 ± 3.23; p=0.950) nor in motility (30.52 ± -5.29; p=103). In the group treated with antioxidants, we had a reduction in caspase-3 activity (2.21 ± 0.62; p <0.001), whereas in the placebo group the mean caspase-3 activity had no statistically significant changes (4.05 ± 0.73; p=0.275). Such therapy seeing the cost-benefit of the same in situations when the consequence of male infertility is increased free radical activity is justified and contributes positively to the process of conceiving natural fertilization.

Item Type:	Article
Uncontrolled Keywords:	Male Infertility, antioxidants, caspase-3, fertilization
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User:	Unnamed user with email zshi@unite.edu.mk
Date Deposited:	23 Sep 2022 08:55
Last Modified:	23 Sep 2022 08:55
URI:	http://eprints.unite.edu.mk/id/eprint/970

Actions (login required)

View Item